In the current research, a novel poly(ε-caprolactone) nanofibrous composite scaffold including CZF-NPs¹ (cobalt‑zinc ferrite nanoparticles) was investigated to study the physical, mechanical and biological properties of new magnetic nanofibrous materials and then to evaluate the effect of applied electromagnetic field on biological properties of these scaffolds. It was observed that the incorporation of CZF-NPs up to 3 wt.% leads to decrease in nanofibers' diameter to 466 nm. By raising the content of CZF-NPs, hydrophilicity and biodegradation of magnetic nanofibrous scaffolds improved significantly. In addition, the mechanical properties of nanofibers such as stress at break point was interestingly increased in the sample with 3 wt.% of CZF-NPs. The results of biocompatibility, cell adhesion and cell staining assays with L929 cells are much more improved in nanofibers embedded with CZF-NPs in the presence of external electromagnetic field (EMF). According to this study, magnetic nanofibrous scaffolds composed of PCL/CZF-NPs could be considered as a promising candidate to regenerate damaged tissues.

在当前的研究中，一种新型的包括CZF-NPs的聚（ε-己内酯）纳米纤维复合支架¹研究了钴锌铁氧体纳米粒子，以研究新型磁性纳米纤维材料的物理，机械和生物学特性，然后评估施加的电磁场对这些支架的生物学特性的影响。观察到，掺入高达3重量％的CZF-NP导致纳米纤维的直径减小至466nm。通过提高CZF-NPs的含量，磁性纳米纤维支架的亲水性和生物降解得到了显着改善。另外，在具有3重量％的CZF-NP的样品中，纳米纤维的机械性能例如断裂点的应力有趣地增加了。生物相容性的结果，在存在外部电磁场（EMF）的情况下，在嵌入CZF-NP的纳米纤维中，L929细胞的细胞粘附和细胞染色测定法得到了更大的改善。根据这项研究，由PCL / CZF-NPs组成的磁性纳米纤维支架可以被认为是再生受损组织的有希望的候选者。