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Genomic insights into antioxidant activities of Pyruvatibacter mobilis CGMCC 1.15125T, a pyruvate-requiring bacterium isolated from the marine microalgae culture
Marine Genomics ( IF 1.3 ) Pub Date : 2020-06-19 , DOI: 10.1016/j.margen.2020.100791
Jin-Cheng Rong 1 , Bo-Wen Ji 1 , Ning Zheng 1 , Zhong-Zhi Sun 1 , Yi-Song Li 1 , Bin-Bin Xie 1
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Pyruvate is a well-known scavenger of reactive oxygen species (ROS) like hydrogen peroxide and could prevent cells from oxidative damage. A pyruvate-requiring marine bacterium, Pyruvatibacter mobilis CGMCC 1.15125T (=KCTC 42509T), was isolated from the culture broth of a photosynthetic marine microalga. Here we report the complete genome sequence of Pyruvatibacter mobilis, which contained a circular chromosome of 3,333,914 bp with a mean G + C content of 63.9%. Through genomic analysis, we revealed that strain CGMCC 1.15125T encodes genes for some antioxidants like superoxide dismutase, glutathione, rubrerythrin and globin to relieve cellular oxidative stress, while pyruvate added to the medium may reduce extracellular ROS. The genome features of P. mobilis provide further insights into the antioxidant activities of bacteria surviving in oxygen-enriched habitats.



中文翻译:

Pyruvatibacter mobilis CGMCC 1.15125T 抗氧化活性的基因组学见解,一种从海洋微藻培养物中分离的需要丙酮酸的细菌

丙酮酸盐是众所周知的活性氧 (ROS) 清除剂,如过氧化氢,可以防止细胞氧化损伤。从光合海洋微藻的培养液中分离出需要丙酮酸的海洋细菌Pyruvatibacter mobilis CGMCC 1.15125 T (= KCTC 42509 T )。在这里,我们报告了运动丙酮酸杆菌的完整基因组序列,其中包含一个 3,333,914 bp 的环状染色体,平均 G + C 含量为 63.9%。通过基因组分析,我们发现菌株 CGMCC 1.15125 T编码一些抗氧化剂的基因,如超氧化物歧化酶、谷胱甘肽、红红蛋白和珠蛋白,以减轻细胞氧化应激,而添加到培养基中的丙酮酸可能会减少细胞外 ROS。P. mobilis的基因组特征为在富氧栖息地中生存的细菌的抗氧化活性提供了进一步的见解。

更新日期:2020-06-19
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