Abstract In this paper, we report the synthesis and evaluation of a polyvinyl alcohol/chitosan (PVA/chitosan) hydrogel incorporated with green synthesized cerium oxide nanoparticles (CeO2-NPs) using a Zingiber officinale extract as the reducing, capping and stabilizer agent for wound healing applications. The PVA/chitosan/CeO2-NPs hydrogel was synthesized via the freeze-thaw technique with 0 to 1% (wt) 5 nm CeO2-NPs. Results revealed that the hydrogels containing 0.5% of CeO2-NPs showed better antibacterial activities after just 12 hr (with MRSA but not E. coli) and healthy human dermal fibroblast viabilities up to 5 days (more than 90%) compared to the control group. Therefore, these chitosan/PVA hydrogels incorporated with Ce-NPs could be a potential candidate as a robust wound dressing agent that impressively may decrease wound infections without resorting to the use of antibiotics.

中文翻译：

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用于伤口愈合应用的含有绿色合成氧化铈纳米颗粒的壳聚糖/PVA 水凝胶

摘要 在本文中，我们报告了使用生姜提取物作为伤口的还原剂、封端剂和稳定剂，合成并评估了掺入绿色合成氧化铈纳米粒子 (CeO2-NPs) 的聚乙烯醇/壳聚糖 (PVA/壳聚糖) 水凝胶。治疗应用。PVA/壳聚糖/CeO2-NPs 水凝胶是通过冻融技术与 0 到 1% (wt) 5 nm CeO2-NPs 合成的。结果表明，与对照组相比，含有 0.5% CeO2-NPs 的水凝胶在 12 小时后（MRSA 但不是大肠杆菌）显示出更好的抗菌活性和健康人皮肤成纤维细胞的活力长达 5 天（超过 90%） . 所以，