Indonesia is hyper-endemic for dengue. Dengue virus non-structural protein 1 (NS1) antigen detection is now increasingly used by clinicians in Indonesia to confirm dengue infection, but many available brands have not had any evaluation on their performance. We evaluated the diagnostic accuracy of 5 different brands of NS1 rapid tests against reference standards consisting of 100 virologically confirmed dengue samples covering all 4 serotypes and 49 non-dengue samples. These rapid tests had sensitivity ranging from 73% to 80%, and specificity of 100%. The tests had better sensitivity for detection during the first 4 days of fever, for DENV-3 serotype, and in primary infections. The evaluated tests can be easily used with adequate sensitivity, very good specificity, and no significant difference in performance between brands. However, certain characteristics such as age, fever day onset, serotype, and immunologic status may affect the accuracy of these tests and need to be taken into consideration.

印度尼西亚是登革热的地方病。印尼的临床医生现在越来越多地使用登革热病毒非结构蛋白1（NS1）抗原检测来确认登革热感染，但是许多可用品牌对其性能没有任何评估。我们根据参考标准评估了5个不同品牌的NS1快速测试的诊断准确性，这些参考标准包括100个经过病毒学确认的登革热样品，涵盖所有4种血清型和49个非登革热样品。这些快速测试的灵敏度范围为73％至80％，特异性为100％。这些测试对于发烧的前4天，DENV-3血清型和原发感染具有更好的检测灵敏度。经评估的测试可以容易地以足够的敏感性，非常好的特异性使用，并且各品牌之间的性能没有显着差异。然而，