Mitochondrial outer membrane permeabilization (MOMP) is a crucial event enabling apoptotic cell death. In this issue of Developmental Cell, Wang et al. reveal an interaction contributing to full MOMP execution, which depends on endosomes accumulating on apoptotic mitochondria. This causes mitochondrial lipid alterations that may contribute to functional pore assembly.

中文翻译：

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致命的相遇：内体与线粒体相遇，引发细胞凋亡。

线粒体外膜通透性（MOMP）是导致凋亡细胞死亡的关键事件。在本期《发育细胞》中，Wang等人。揭示了一种相互作用，有助于完全执行MOMP，这取决于核糖体在凋亡的线粒体上积累。这会导致线粒体脂质改变，这可能有助于功能性的毛孔组装。