It remains unclear how intercellular force transmission is coupled with intracellular biochemical signaling to achieve collective cell migration. In this issue of Developmental Cell, Hino et al. demonstrate that intracellular ERK signaling propagates as waves across a tissue and couples with intercellular mechano-transduction to direct epithelial cell migration.

中文翻译：

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在集体细胞迁移中掀起波澜。

尚不清楚如何将细胞间的力传递与细胞内的生化信号传导结合起来以实现集体细胞迁移。在这一期的《发育细胞》中，Hino等人。证明细胞内ERK信号以波的形式在组织中传播，并与细胞间机械传导耦合以指导上皮细胞迁移。