Organ fibrosis represents a default tissue program activated when regenerative capacity is limited. In this issue of Developmental Cell, Ding et al. identify a lipid signaling pathway involving the liver synthesized chaperone ApoM as a circulating pro-regenerative mediator that is deficient in aging and mitigates fibrosis in distant organs.

中文翻译：

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青年药剂：在肝脏中合成的脂质信号分子伴侣。

器官纤维化代表再生能力有限时激活的默认组织程序。在本期《发育细胞》中，丁等人。鉴定涉及肝脏合成的伴侣蛋白ApoM的脂质信号传导途径，该途径是衰老不足并减轻远处器官纤维化的循环前再生介质。