BACKGROUND Z. multiflora effect on clinical symptoms, pulmonary function tests (PFT), oxidative stress and cytokine levels in asthmatic patients were evaluated. METHODS 36 asthmatic patients were divided to; placebo group (P), two groups treated with Z. multiflora extract (5 and 10 mg/kg/day, as Z5 and Z10, respectively), (n = 12 in each group). Medications were administered three times a day for two months and several parameters were evaluated before treatment (step 0), one (step 1) and two months (step 2) after treatment. RESULTS Clinical symptoms and PFTs were significantly improved in Z5 and Z10 groups in steps 1 and 2 compared to step 0 (p < 0.05 to p < 0.001). Improvement of oxidative stress, cytokines levels and their gene expression after treatment with both doses of extract were observed in step 2 compared to step 0 (p < 0.05 to p < 0.001). CONCLUSION These results indicated therapeutic value of Z. multiflora for the management of asthma.

中文翻译：

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Zataria multiflora 影响哮喘患者的临床症状、氧化应激和细胞因子：一项随机、双盲、安慰剂对照、II 期临床试验

背景 对哮喘患者的临床症状、肺功能测试 (PFT)、氧化应激和细胞因子水平的多菌群的影响进行了评估。方法将36例哮喘患者分为：安慰剂组 (P)，两组用 Z. multiflora 提取物（5 和 10 mg/kg/天，分别作为 Z5 和 Z10）（每组 n = 12）。药物每天给药 3 次，持续两个月，治疗前（第 0 步）、第 1 步（第 1 步）和治疗后两个月（第 2 步）评估几个参数。结果 与步骤 0 相比，Z5 和 Z10 组在步骤 1 和步骤 2 中的临床症状和 PFT 显着改善（p < 0.05 至 p < 0.001）。与步骤 0 相比，在步骤 2 中观察到用两种剂量的提取物处理后氧化应激、细胞因子水平及其基因表达的改善（p < 0. 05 至 p < 0.001）。结论 这些结果表明多花酵母对哮喘的治疗具有治疗价值。