Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of bone under physiological conditions and numerous pathological conditions, such as osteoporosis, bone metastasis, and inflammatory bone erosion. Nuclear receptors are crucial to various physiological processes, including metabolism, development and inflammation, and function as transcription factors to activate target genes. Synthetic ligands of nuclear receptors are also available for the treatment of metabolic and inflammatory diseases. However, dysregulated bone phenotypes have been documented in patients who take synthetic nuclear receptor ligands as a therapy. Therefore, the effect of nuclear receptors on bone cells has become an important area of exploration; additionally, the molecular mechanisms underlying the action of nuclear receptors in osteoclasts have not been completely understood. Here, we cover the recent progress in our understanding of the roles of nuclear receptors in osteoclasts.

破骨细胞是骨吸收细胞，在生理条件和许多病理条件下（例如骨质疏松、骨转移和炎性骨侵蚀）下的骨重塑中发挥重要作用。核受体对各种生理过程至关重要，包括新陈代谢、发育和炎症，并作为转录因子激活靶基因。核受体的合成配体也可用于治疗代谢和炎症疾病。然而，在采用合成核受体配体作为治疗的患者中已记录了骨表型失调。因此，核受体对骨细胞的影响已成为重要的探索领域；此外，破骨细胞核​​受体作用的分子机制尚未完全了解。在这里，我们介绍了我们对破骨细胞中核受体作用的理解的最新进展。