Phenolic acids from Q.Infectoria (QI) galls were extracted using focused–type ultrasound extraction method and further optimized using sequential optimization by response surface methodology (RSM). Different independent variables of sonication time, A (6–10 h), solvent concentration, B (0.05–0.15 M), ratio, C (1:05–1:15), duty cycle, D (30–50 %) and temperature, E (60–80 °C) were first screened via full factorial design (FFD) and the obtained results indicated that sonication time, ratio and temperature were the most significant variables in attaining higher yields. The significant curvature from focused–type ultrasound performance provides insights to a subsequent optimization of the factorial model via face–centred central composite design (FCCCD). The later results revealed that temperature highly impacted the yield with highest contribution percentage of 56.76 %. Notably, maximum extraction yield of 4119.77 mg/g was achieved at optimum condition of 9 h sonication time, ratio of 1:6 and temperature of 75 °C. Besides, Fick’s model successfully promotes diffusivity and appropriately foreseen that temperature factor governed the extraction process from QI galls. Relevant activation energy of 83.39 J/mol, along with the thermodynamic factors which include activation enthalpy (ΔH*) and activation Gibbs free energy (ΔG*), affirmed the extraction process was endothermic and non-spontaneous in identity.

使用聚焦型超声提取方法提取了Q. Infectoria（QI）胆汁中的酚酸，并使用响应面方法（RSM）进行了顺序优化，从而进一步进行了优化。超声处理时间，A（6–10 h），溶剂浓度，B（0.05–0.15 M），比率，C（1：05–1：15），占空比，D（30–50％）和温度，E（60–80°C）首先通过全因子设计（FFD）进行了筛选，所得结果表明，超声处理时间，比例和温度是获得更高收率的最重要变量。聚焦型超声性能产生的显着曲率，可以通过以面心为中心的中央复合设计（FCCCD）提供见解，从而进一步优化阶乘模型。后来的结果表明，温度对产量的影响最大，贡献率最高为56.76％。值得注意的是，在9 h超声处理时间，1：6的比例和75°C的温度下的最佳条件下，最大提取产量为4119.77 mg / g。此外，Fick模型成功地促进了扩散，并适当地预见了温度因素决定了从QI胆汁中提取的过程。相关活化能为83.39 J / mol，