Despite the advantages of mesoporous silica nanoparticles (MSNs) in drug delivery, the inherent non-biodegradability seriously impedes the clinical translation of inorganic MSNs, so the current research focus has been turned to mesoporous organosilica nanoparticles (MONs) with higher biocompatibility and easier biodegradability. Recent remarkable advances in silica fabrication chemistry have catalyzed the emergence of a library of MONs with various structures and functions. This review will summarize the latest state-of-the-art studies on the precise control of morphology, structure, framework, particle size and pore size of MONs, which enables the precise synthesis of MONs with suitable engineering for precision stimuli-responsive drug delivery/release, bioimaging and synergistic therapy. Besides, the potential challenges about the future development of MONs are also outlooked with the intention of attracting more researchers to promote the clinical translation of MONs.

尽管介孔二氧化硅纳米颗粒（MSNs）在药物输送中具有优势，但固有的非生物降解性严重阻碍了无机MSNs的临床转化，因此当前的研究重点已转向具有更高生物相容性和更易生物降解性的介孔有机二氧化硅纳米颗粒（MONs）。二氧化硅制造化学领域最近的显着进步催化了具有各种结构和功能的MONs库的出现。这篇综述将总结关于MONs的形态，结构，构架，粒径和孔径的精确控制的最新技术研究，这使得能够以合适的工程技术精确合成MONs来进行精确的刺激响应药物递送。 /释放，生物成像和协同治疗。除了，