Epidemiological studies have linked exposure to heavy metals and increased blood pressure (BP). We conducted a repeated measures study to examine the associations between airborne heavy metals and BP, and we looked at effect modification by participant characteristics. We assessed blood cadmium (B–Cd), lead (B–Pb), and mercury (B–Hg), and studied measurements of systolic (SBP) and diastolic (DBP) blood pressure on 140 traffic enforcers from the Metropolitan Manila Development Authority Traffic Enforcers’ Health Study. Linear mixed-effects models with random subject-specific intercepts were fitted to estimate the effect of B-CD, B–Pb, and B–Hg exposure on the percent change in mean SBP and DBP, adjusting for potential confounding factors. Moreover, effect modification by sex and obesity were assessed. B–Pb and B–Cd concentrations were related to increased BP. A unit (1.0 μg/dL) increase in B–Pb was associated with 2.5% [95% confidence interval (CI): 1.3–3.7] and 2.1% (95% CI: 0.7–3.5) increases in mean SBP and DBP, respectively. A similar result was observed for the effect of B–Cd on SBP (2.2% increase, 95% CI: 0.6–3.7) but not on DBP (0.9% increase, 95% CI: −0.9–2.7). However, no association between B–Hg and BP was observed. The associations between B–Pb and both DBP and SBP were stronger among males (SBP: 2.7% increase, 95% CI: 1.5–4.0; DBP: 2.3% increase, 95% CI: 0.8–3.7) versus females, or traffic enforcers who were nonobese (SBP: 2.8% increase, 95% CI: 1.5–4.2; DBP: 2.9% increase, 95% CI: 1.3–4.4) versus obese. In summary, B–Pb and B–Cd are associated with increased BP. B–Pb may both increase SBP and DBP among male, or nonobese traffic enforcers.

流行病学研究表明，接触重金属与血压升高（BP）有关。我们进行了一项反复​​的措施研究，以检查空气中重金属与BP之间的关联，并研究了参与者特征对效果的影响。我们评估了血液中的镉（B–Cd），铅（B–Pb）和汞（B–Hg），并研究了马尼拉大都会发展管理局对140名交通执法者的收缩压（SBP）和舒张压（DBP）的测量结果交通执法者健康研究。拟合具有特定受试者随机截距的线性混合效应模型，以估计B-CD，B-Pb和B-Hg暴露对平均SBP和DBP百分比变化的影响，并调整了潜在的混杂因素。此外，评估了性别和肥胖对效果的影响。B–Pb和B–Cd浓度与血压升高有关。B-Pb单位增加（1.0μg/ dL）与SBP和DBP平均增加2.5％[95％置信区间（CI）：1.3-3.7]和2.1％（95％CI：0.7-3.5）相关，分别。观察到B-Cd对SBP的影响（增加2.2％，95％CI：0.6-3.7），但对DBP的影响（增加0.9％，95％CI：-0.9-2.7）也观察到类似的结果。但是，没有观察到BHg与BP之间的关联。与女性或交通执法者相比，男性中B–Pb与DBP和SBP的关联性更强（SBP：增加2.7％，95％CI：1.5–4.0； DBP：增加2.3％，95％CI：0.8–3.7）。非肥胖者（肥胖）（SBP：增加2.8％，95％CI：1.5-4.2； DBP：增加2.9％，95％CI：1.3-4.4）。总之，B–Pb和B–Cd与血压升高有关。B–Pb可能会增加男性的SBP和DBP，