Circulating tumor cells (CTCs) are extremely scarce cells which cut off from a primary tumor and percolate into the circulation of blood flow and are, thus, critical for precise cancer detection and treatment. Deterministic lateral displacement (DLD) which exploits asymmetric splitting of laminar flow around the implanted microposts has displayed trustworthy capabilities in separating cells of varying sizes. In this research work, a microfluidic channel consisting of three symmetrically aligned inlets and outlets and embedded circular posts has been proposed which effectively separates the CTCs from lymphocytes utilizing the concept of DLD. Using a commercial software COMSOL Multiphysics 5.4, the design of the proposed microchannel has been simulated and analyzed considering an injected blood sample containing massive CTCs and slim WBCs of radii 13.5 µm and 6 µm, respectively. The proposed model of microchannel isolates the CTCs from WBCs at a comparatively higher sample mass flow rate of 4 × 10^–6 kg/s and Reynolds number of 8.9 thereby operating efficiently at higher throughput, and offers excellent linearity in terms of velocity magnitude, pressure, shear rate and Reynolds number. The computational analysis of the proposed microchannel reveals that it can isolate CTCs from WBCs with better separation ratio, offers higher throughput, reduces possibilities of clogging and maintains better uniformity of pressure distribution and other flow parameters when compared with existing microchannel designs. The maximum separation ratio for CTCs and WBCs has been obtained as 84% and 96%, respectively.

循环肿瘤细胞（CTC）是极为稀少的细胞，可从原发肿瘤切下并渗入血流循环，因此对于精确的癌症检测和治疗至关重要。确定性横向位移（DLD）利用围绕植入微柱的层流的不对称分裂，在分离大小不同的单元格方面显示出可信赖的能力。在这项研究工作中，已经提出了由三个对称排列的入口和出口以及嵌入式圆形柱组成的微流体通道，该通道利用DLD的概念有效地将CTC与淋巴细胞分离。使用商业软件COMSOL Multiphysics 5.4，拟议的微通道的设计已经被模拟和分析，考虑到所注入的血液样本分别含有大的CTC和半径分别为13.5 µm和6 µm的细白细胞。拟议的微通道模型以4×10的较高样品质量流速从WBC中分离出四氯化碳^–6  kg / s和8.9的雷诺数，从而可在更高的吞吐量下高效运行，并且在速度大小，压力，剪切速率和雷诺数方面均具有出色的线性度。对拟议中的微通道的计算分析表明，与现有的微通道设计相比，它可以以更好的分离率从白细胞中分离出四氯化碳，提供更高的通量，减少堵塞的可能性，并保持更好的压力分布均匀性和其他流量参数。CTC和WBC的最大分离率分别为84％和96％。