Abstract

Three-component condensation of propan-2-one with formaldehyde and propane-2-thiol in the presence of sodium hydroxide afforded 3-{[(propan-2-yl)sulfanyl)]methyl}but-3-en-2-one or 4-[(propan-2-yl)sulfanyl]-3-{[(propan-2-yl)sulfanyl]methyl}butan-2-one, depending on the amount of the base. The formation of 4-[(propan-2-yl)sulfanyl]-3-{[(propan-2-yl)sulfanyl]methyl}butan-2-one from 4-[(propan-2-yl)sulfanyl]butan-2-one involved aldol condensation of the latter with formaldehyde and subsequent nucleophilic addition of propane-2-thiol to the C=C double bond of intermediate 3-{[(propan-2-yl)sulfanyl]methyl}but-3-en-2-one in the presence of sodium hydroxide.

中文翻译：

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丙-2-酮与甲醛和丙-2-硫醇的缩合

摘要

在氢氧化钠的存在下，丙-2-酮与甲醛和丙烷-2-硫醇的三组分缩合，得到3-{[[（丙-2-基）硫烷基]]甲基} but-3-en-2-one或4-[（丙-2-基）硫烷基] -3-{[（（丙-2-基）硫烷基]甲基}丁烷-2-酮，取决于碱的量。由4-[（丙-2-基）硫烷基]丁烷形成4-[（丙-2-基）硫烷基] -3-{[（丙-2-基）硫烷基]甲基}丁-2-酮。 -2-一涉及后者与甲醛的醛醇缩合，随后将丙-2-硫醇亲核加成至中间体3-{[（（丙-2-基）硫烷基]甲基} but-3-的C = C双键上en-2-one在氢氧化钠存在下。