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Condensation of Propan-2-one with Formaldehyde and Propane-2-thiol
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2020-06-20 , DOI: 10.1134/s1070363220040015 L. A. Baeva , R. M. Nugumanov , L. F. Biktasheva , R. L. Safiullin
中文翻译:
丙-2-酮与甲醛和丙-2-硫醇的缩合
更新日期:2020-06-20
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2020-06-20 , DOI: 10.1134/s1070363220040015 L. A. Baeva , R. M. Nugumanov , L. F. Biktasheva , R. L. Safiullin
Abstract
Three-component condensation of propan-2-one with formaldehyde and propane-2-thiol in the presence of sodium hydroxide afforded 3-{[(propan-2-yl)sulfanyl)]methyl}but-3-en-2-one or 4-[(propan-2-yl)sulfanyl]-3-{[(propan-2-yl)sulfanyl]methyl}butan-2-one, depending on the amount of the base. The formation of 4-[(propan-2-yl)sulfanyl]-3-{[(propan-2-yl)sulfanyl]methyl}butan-2-one from 4-[(propan-2-yl)sulfanyl]butan-2-one involved aldol condensation of the latter with formaldehyde and subsequent nucleophilic addition of propane-2-thiol to the C=C double bond of intermediate 3-{[(propan-2-yl)sulfanyl]methyl}but-3-en-2-one in the presence of sodium hydroxide.中文翻译:
丙-2-酮与甲醛和丙-2-硫醇的缩合