Abstract

The amidoalkylation reactions of a phosphonous acid containing a structural isostere of leucine in acetyl chloride and(or) acetic anhydride were studied under conditions of acid catalysis. A two-component method for the synthesis of a phosphinic analogue of alanylleucine using ethylidenebis(benzylcarbamate) was proposed.

中文翻译：

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丙氨酰亮氨酸的膦酸酯类似物的合成

摘要

在酸催化条件下，研究了含有亮氨酸结构等位异构体的亚磷酸在乙酰氯和（或）乙酸酐中的酰胺烷基化反应。提出了使用亚乙基双（苄基氨基甲酸酯）合成丙氨酰亮氨酸的次膦酸酯类似物的两组分方法。