Abstract

Synthesis of regioisomeric 8-trifluoromethyl-4,5-dihydro-3H-imidazo[4',5':5,6]benz[1,2-d]isoxazoles and 8-trifluoromethyl-4,5-dihydro-3H-imidazo[4',5':3,4]benz[1,2-c]isoxazolones was realized by one-pot oxidation of 3-trifluromethyl-6,7-dihydrobenz[d]- or [c]isoxazoles with selenium dioxide in glacial acetic acid followed by a condensation of formed in situ 3-trifluromethyl-6,7-dihydrobenz[d]- or [c]isoxazole-4,5-diones with benzaldehydes in the presence of ammonium acetate.

中文翻译：

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一锅法合成三氟甲基取代的咪唑并苯并[1,2-d]-和-[1,2-c]异恶唑

摘要

区域异构的8-三氟甲基-4,5-二氢-3 H-咪唑并[4'，5'：5,6]苯并[1,2- d ]异恶唑和8-三氟甲基-4,5-二氢-3 H -咪唑并[4'，5'：3,4]苯并[1,2 -c ]异恶唑酮是通过用硒一锅氧化3-三氟甲基-6,7-二氢苯并[ d ]-或[ c ]异恶唑来实现的在冰醋酸中加入二氧化氯，然后在乙酸铵存在下，将形成的原位3-三氟甲基-6,7-二氢苯并[ d ]-或[ c ]异恶唑-4,5-二酮与苯甲醛缩合。