5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses,Russian Journal of Bioorganic Chemistry

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5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses
Russian Journal of Bioorganic Chemistry ( IF 1 ) Pub Date : 2020-05-01 , DOI: 10.1134/s1068162020030139
Y V Nikolayeva ₁ , E A Ulashchik ₂ , E V Chekerda ₁ , A V Galochkina ₁ , N A Slesarchuk _{3,

4,

5} , A A Chistov _{3,

5} , T D Nikitin _{3,

4} , V A Korshun _{3,

5,

6} , V V Shmanai ₂ , A V Ustinov _{3,

5} , A A Shtro ₁

Affiliation

Abstract In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (PIV-3); and human respiratory syncytial virus (RSV). Related known compounds were also analyzed: 5-(perylen-3-ylethynyl)-2′-deoxy-uridine; 5-(perylen-3-ylethynyl)-arabino-uridine; and 1-carboxymethyl-3-pivaloyloxymethyl-5-(perylen-3-ylethynyl)uracil.

中文翻译：

5-(Perylen-3-ylethynyl)uracil 衍生物抑制呼吸道病毒的繁殖

摘要在这项工作中，我们描述了 5-(perylen-3-ylethynyl)uridine 的合成及其在细胞培养中有效抑制呼吸道疾病病原体复制的能力，即：甲型流感病毒 (IVA)；3型副流感病毒（PIV-3）；和人类呼吸道合胞病毒 (RSV)。还分析了相关的已知化合物：5-(perylen-3-ylethynyl)-2'-脱氧-尿苷；5-(perylen-3-ylethynyl)-阿拉伯尿苷；和 1-carboxymethyl-3-pivaloyloxymethyl-5-(perylen-3-ylethynyl)uracil。

更新日期：2020-05-01

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