Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we reported a novel super-paramagnetic iron oxide (SPIO) based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose. This polyethylene glycol with four phenylboronic acid (PEG-B4)/CNTs@porphyrin (ph)/SPIO (BCPS) nanoplatform was simply prepared via integrated SPIO, ph, and a novel dendrimer with PEG liner and four PBA groups (PEG-B4) on the surface of carbon nanotubes (CNTs). Subsequently, a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering. Moreover, the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy. Furthermore, the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4. We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor (1 mm) in the liver, but also effectively ablate tumors in a xenograft model, thereby achieving a complete cure rate of 100% at low laser dose. Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

已经证明了可以增加成像诊断的准确性并提高治疗功效的对微肿瘤敏感的治疗药物纳米剂的构建对于癌症的诊断和治疗是一种有前途的方法。在这里，我们报道了一种新型的基于超顺磁性氧化铁（SPIO）的纳米平台，该纳米平台具有显着增强的磁共振特性和光热效应，可用于肿瘤治疗学目的。带有四个苯基硼酸（PEG-B4）/ CNTs @卟啉（ph）/ SPIO（BCPS）纳米平台的聚乙二醇是通过集成的SPIO，ph和具有PEG内衬和四个PBA基团的新型树枝状聚合物（PEG-B4）简便地制备的在碳纳米管（CNT）的表面上。随后，通过减少水对SPIO群集的可及性，可以实现显着提高的T2松弛率。此外，BCPS纳米平台协同增强的光热作用为癌症治疗提供了更好的光热作用。此外，从PEG-B4的苯基硼酸进一步引入了对唾液酸过表达的肿瘤的靶向能力。我们表明，BCPS纳米平台不仅可以选择性地识别实体瘤并检测肝脏中的微小转移性肿瘤（1毫米），而且可以在异种移植模型中有效消融肿瘤，从而在低激光剂量下达到100％的完全治愈率。我们的结果突出了BCPS纳米平台在准确的微肿瘤诊断和有效的肿瘤治疗中的潜力。从PEG-B4的苯基硼酸进一步引入了对唾液酸过表达的肿瘤的靶向能力。我们表明，BCPS纳米平台不仅可以选择性地识别实体瘤并检测肝脏中的微小转移性肿瘤（1毫米），而且可以在异种移植模型中有效消融肿瘤，从而在低激光剂量下达到100％的完全治愈率。我们的结果突出了BCPS纳米平台在准确的微肿瘤诊断和有效的肿瘤治疗中的潜力。从PEG-B4的苯基硼酸中进一步引入了对唾液酸过表达的肿瘤的靶向能力。我们表明，BCPS纳米平台不仅可以选择性地识别实体瘤并检测肝脏中的微小转移性肿瘤（1毫米），而且可以在异种移植模型中有效消融肿瘤，从而在低激光剂量下达到100％的完全治愈率。我们的结果突出了BCPS纳米平台在准确的微肿瘤诊断和有效的肿瘤治疗中的潜力。