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Pseudorabies virus encephalitis in humans: a case series study.
Journal of Neurovirology ( IF 2.3 ) Pub Date : 2020-06-22 , DOI: 10.1007/s13365-020-00855-y
Siyuan Fan 1 , Hongxun Yuan 2 , Lei Liu 3 , Hongfang Li 4 , Shengnan Wang 5 , Weili Zhao 6 , Yihan Wu 7 , Pei Wang 8 , Yafang Hu 5 , Jun Han 9 , Yanli Lyu 10 , Wuchao Zhang 9 , Peng Chen 9 , Honglong Wu 11 , Yanping Gong 11 , Zhenzi Ma 11 , Yongjun Li 12 , JiaoJiao Yu 2 , Xiaodong Qiao 6 , Guoli Li 6 , Yan Zhao 7 , Dexin Wang 13 , Haitao Ren 1 , Bin Peng 1 , Liying Cui 1 , Jiawei Wang 3 , Hongzhi Guan 1
Affiliation  

Pseudorabies virus (PRV) is known to cause severe encephalitis in juvenile pigs and various non-native hosts; recent evidences suggest that PRV might cause encephalitis in humans. In a multicenter cohort study in China, next-generation sequencing of cerebrospinal fluid (CSF) was performed to detect pathogens in all patients with clinically suspected central nervous system infections. This study involved all the patients whose CSF samples were positive for PRV-DNA; their clinical features were evaluated, and species-specific PCR and serological tests were sequentially applied for validation. Among the 472 patients tested from June 1, 2016, to December 1, 2018, six were positive for PRV-DNA, which were partially validated by PCR and serological tests. Additionally, we retrospectively examined another case with similar clinical and neuroimaging appearance and detected the presence of PRV-DNA. These patients had similar clinical manifestations, including a rapid progression of panencephalitis, and similar neuroimaging features of symmetric lesions in the basal ganglia and bilateral hemispheres. Six of the patients were engaged in occupations connected with swine production. PRV infection should be suspected in patients with rapidly progressive panencephalitis and characteristic neuroimaging features, especially with exposure to swine.

更新日期:2020-06-23
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