Purpose

The aims of this study were to investigate the correlation of sex hormone-binding globulin (SHBG) and the components of metabolic syndrome (MetS) and explore the ability of SHBG to predict MetS in newly diagnosed and untreated patients with polycystic ovary syndrome (PCOS).

Methods

Ninety-eight newly diagnosed and untreated patients with PCOS and 37 healthy volunteers were recruited. A receiver operating characteristic (ROC) curve was used to explore the best cutoff values of SHBG for predicting that the patients with PCOS would fulfill at least one abnormal index of MetS components, at least two abnormal indexes of MetS components, or MetS.

Results

The numbers of patients with PCOS who fulfilled none, one, or two of the MetS criteria items and MetS were 33, 31, 19, and 15, respectively. SHBG was negatively correlated with BMI (r = − 0.615, P < 0.001), systolic blood pressure (SBP) (r = − 0371, P < 0.001), diastolic blood pressure (DBP) (r = − 0.285, P = 0.004), triglycerides (TG) (r = − 0.431, P < 0.001), fasting serum insulin (I₀) (r = − 0.549, P < 0.001), HOMA-IR (r = − 0.557, P < 0.001), and plasma glucose 2 h after glucose load (G₁₂₀) (r = − 0.337, P < 0.001) and positively correlated with high-density lipoprotein cholesterol (HDL-C) (r = 0.629, P < 0.001) in patients with PCOS. The optimal cutoff value of SHBG for predicting MetS in patients with PCOS was 21.3 nmol/L, with a sensitivity of 100.0% (95% CI 78.0–100.0%) and specificity of 85.12% (95% CI 77.5–90.9%).

Conclusions

Sixty-five patients had varying degrees of metabolic abnormalities, accounting for 66.3% of the patients with PCOS. SHBG was associated with metabolic indexes, including BMI, SBP, DBP, TG, I₀, HOMA-IR, G₁₂₀, and HDL-C, and can therefore be employed as a useful index for MetS prediction.

中文翻译：

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性激素结合球蛋白在新诊断和未治疗的多囊卵巢综合征患者中预测代谢综合征的功效。

目的

这项研究的目的是调查性激素结合球蛋白（SHBG）与代谢综合征（MetS）的成分之间的关​​系，并探讨SHBG在新诊断和未治疗的多囊卵巢综合征（PCOS）患者中预测MetS的能力。 。

方法

招募了98名新诊断和未治疗的PCOS患者和37名健康志愿者。使用受试者工作特征（ROC）曲线探索SHBG的最佳临界值，以预测PCOS患者将满足至少一个MetS组分异常指标，至少两个MetS组分异常指标或MetS。

结果

没有满足一项，一项或两项MetS标准项目和MetS的PCOS患者分别为33、31、19和15。SHBG与BMI呈负相关（r  = − 0.615，P  <0.001），收缩压（SBP）（r  = − 0371，P  <0.001），舒张压（DBP）（r  = − 0.285，P  = 0.004） ，甘油三酸酯（TG）（r  = − 0.431，P  <0.001），空腹血清胰岛素（I ₀）（r  = − 0.549，P  <0.001），HOMA-IR（r  = − 0.557，P  <0.001）和血浆葡萄糖负荷后2 h血糖（G₁₂₀）（r  = − 0.337，P  <0.001），并 与PCOS患者的高密度脂蛋白胆固醇（HDL-C）正相关（r  = 0.629，P <0.001）。预测PCOS患者MetS的最佳SHBG临界值为21.3 nmol / L，灵敏度为100.0％（95％CI 78.0-100.0％），特异性为85.12％（95％CI 77.5-90.9％）。

结论

65例患者有不同程度的代谢异常，占PCOS患者的66.3％。SHBG与代谢指标相关，包括BMI，SBP，DBP，TG，I ₀，HOMA-IR，G ₁₂₀和HDL-C，因此可以用作MetS预测的有用指标。