Background

Methylsulfonylmethane (MSM) is a commonly used diet supplement believed to decrease the inflammation in joints and fastens recovery in osteoarthritis, gastric mucosal injury, or obesity-related disorders. It was also suggested that MSM might play a beneficial role in cancer treatment.

Purpose

So far, the MSM might have a potentially beneficial effect in endometrial cancer (EC) treatment.

Study design

This study evaluated the effect and usefulness of MSM in combinatory therapy with known drug doxorubicin (DOX).

Methods

The effect of combinational treatment of MSM and DOX on the induction of apoptosis was evaluated in EC cell lines (ISHIKAWA, MFE-296, MFE-280).

Results

We observed that MSM itself induces apoptosis in EC cell lines, and pre-treatment with MSM for 24 h increases the sensitivity of EC cells to DOX-induced apoptosis and DNA damage and that effect might be regulated by p42/44 (Erk1/2) MAPK and Akt (protein kinase B).

Conclusion

These results for the first time show that MSM might act as a sensitizer of EC cells to known drugs, for which EC cells quickly acquire resistance.

Graphical abstract

中文翻译：

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甲基磺酰甲烷使子宫内膜癌细胞对阿霉素敏感。

背景

甲基磺酰甲烷 (MSM) 是一种常用的膳食补充剂，据信可减少关节炎症并加快骨关节炎、胃粘膜损伤或肥胖相关疾病的恢复。也有人认为 MSM 可能在癌症治疗中发挥有益作用。

目的

到目前为止，MSM 可能对子宫内膜癌 (EC) 治疗具有潜在的有益作用。

学习规划

本研究评估了 MSM 在与已知药物多柔比星 (DOX) 联合治疗中的效果和有用性。

方法

在 EC 细胞系（ISHIKAWA、MFE-296、MFE-280）中评估了 MSM 和 DOX 联合治疗对诱导细胞凋亡的影响。

结果

我们观察到 MSM 本身诱导 EC 细胞系凋亡，用 MSM 预处理 24 小时会增加 EC 细胞对 DOX 诱导的细胞凋亡和 DNA 损伤的敏感性，这种作用可能受 p42/44 (Erk1/2) 调节MAPK 和 Akt（蛋白激酶 B）。

结论

这些结果首次表明 MSM 可能作为 EC 细胞对已知药物的敏化剂，EC 细胞会迅速获得耐药性。

图形概要