Parabens are widely used as preservatives in personal care products, foodstuffs, and pharmaceuticals. Concerns have been raised regarding the potential endocrine disruption effects of parabens. In the present study, the urinary concentration of four common parabens, including methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP), in 100 Iranian adolescents randomly referring to health services centres were analyzed using GC/MS. The association of sociodemographic and lifestyle variables, collected through questionnaire, with the concentration of parabens also were studied. Median concentrations of MP, EP, PP, and BP were 92.21, 8.46, 12.26, and 8.42 µg/g creatinine, respectively. There was a strong positive significant correlation between MP and PP (r = 0.694) and moderate to a weak correlation between the other parabens. The concentration of urinary MP in females was significantly higher than those in male (p = 0.021). There was a significant negative association between different BMI groups and MP and EP. There also was a positive significant association between the MP and age, and between MP, EP, and PP, and tobacco use. Although the estimated daily intake of the parabens was lower than the Acceptable Daily Intake, it was higher than those reported in other countries. This confirms the widespread exposure of Iranian adolescents to the paraben compounds and their association with sociodemographic factors. This was the first study reporting the urinary parabens level in Iranian adolescents, and the data can be used as a basis for assessing the risk of exposure to parabens in the Iranian population in future studies.

对羟基苯甲酸酯被广泛用作个人护理产品，食品和药品中的防腐剂。对对羟基苯甲酸酯的潜在内分泌干扰作用引起了关注。在本研究中，使用GC / MS分析了随机分配给卫生服务中心的100名伊朗青少年中四种常见对羟基苯甲酸酯的浓度，包括对羟基苯甲酸甲酯（MP），对羟基苯甲酸乙酯（EP），对羟基苯甲酸丙酯（PP）和对羟基苯甲酸丁酯（BP）。多发性硬化症。还研究了通过问卷调查收集的社会人口学和生活方式变量与对羟基苯甲酸酯浓度的关系。MP，EP，PP和BP的中位数浓度分别为肌酐：92.21、8.46、12.26和8.42 µg / g。MP和PP（r = 0.694），而其他对羟基苯甲酸酯之间的相关性中等至较弱。女性的尿MP浓度明显高于男性（p = 0.021）。BMI组与MP和EP之间存在显着的负相关。MP与年龄之间，MP，EP和PP与烟草使用之间也存在显着正相关。尽管估计的对羟基苯甲酸酯的每日摄入量低于可接受的每日摄入量，但高于其他国家报告的摄入量。这证实了伊朗青少年广泛暴露于对羟基苯甲酸酯类化合物中，以及它们与社会人口统计学因素的关系。这是第一项报告伊朗青少年尿液中对羟基苯甲酸酯水平的研究，该数据可作为评估未来人群中伊朗人群对羟基苯甲酸酯暴露风险的基础。