Continuous-flow chemistry is a modern technology that encompasses the green chemistry principles for the multi-gram synthesis of various API and drugs. Herein, we have developed a highly efficient and environmentally benign metal-free alkylation of 1,3-dicarbonyl compounds using secondary alcohols in the presence of inexpensive Amberlyst®-15 under continuous-flow. This method has a broad substrate scope with a variety of secondary alcohols and water as a byproduct. The Amberlyst®-15 is recyclable and reusable for the alkylation reaction under batch/continuous-flow technology. Furthermore, a continuous-flow technology driven Mannich reaction was demonstrated under an acid-free condition. In addition, a continuous-flow Fischer indole strategy for the ondansetron with an improved yield was demonstrated. Additionally, all these reactions were demonstrated with multi-gram scale synthesis without lowering the yield under batch/continuous-flow technology.

中文翻译：

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使用1，3-二羰基化合物连续克数级合成C2-烷基或β-氨基官能化的1,3-二羰基衍生物和恩丹西酮药物的连续流方法

连续流化学是一种现代技术，涵盖了绿色化学原理，可用于多种API和药物的多克合成。本文中，我们在廉价的Amberlyst®-15存在下，在连续流动条件下，使用仲醇开发了一种高效且对环境无害的1,3-二羰基化合物无金属烷基化反应。该方法具有广泛的底物范围，副产物包括各种仲醇和水。-15是可回收的，可在间歇/连续流技术下用于烷基化反应。此外，在无酸条件下证明了采用连续流技术驱动的曼尼希反应。此外，还证明了用于恩丹西酮的连续流费歇尔吲哚策略具有提高的产率。另外，