Liver cancer is one of the most common cancers in the world. The primary aim of this research was to discover the correlation between single nucleotide polymorphisms (SNPs) of the MIR155HG and liver cancer risk. The selected SNPs in MIR155HG were genotyped utilizing the Agena MassARRAY platform. We evaluated the correlation between MIR155HG polymorphisms and Liver cancer by genetic model analysis, stratification analysis and haplotype analysis. Relative risk of Liver cancer was shown based on odds ratios (ORs) and 95% confidence intervals (95% CIs). Our results uncovered that rs12482371 and rs1893650 in the MIR155HG were associated with protection against Liver cancer. And the rs928883 was related to increase risk of Liver cancer. Furthermore, apart from rs77218221, other selected SNPs formed two LD blocks, and haplotype “GATAG” in block 2 elevated individual liver cancer risk. MIR155HG gene polymorphism may be correlated to Liver cancer susceptibility in Han Chinese population, particularly in males and aged ≤55 years.

中文翻译：

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MiRNA155HG基因多态性影响汉族人群患肝癌的风险。

肝癌是世界上最常见的癌症之一。这项研究的主要目的是发现MIR155HG的单核苷酸多态性（SNP）与肝癌风险之间的相关性。利用Agena MassARRAY平台对MIR155HG中选定的SNP进行基因分型。我们通过遗传模型分析，分层分析和单倍型分析评估了MIR155HG基因多态性与肝癌之间的相关性。根据优势比（OR）和95％置信区间（95％CI）显示了肝癌的相对风险。我们的结果发现，MIR155HG中的rs12482371和rs1893650与针对肝癌的保护相关。rs928883与增加肝癌的风险有关。此外，除了rs77218221外，其他选定的SNP还形成了两个LD块，区域2中的单倍型“ GATAG”增加了个体肝癌风险。MIR155HG基因多态性可能与汉族人群中肝癌的易感性有关，特别是在年龄≤55岁的男性中。