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A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-19 , DOI: 10.1039/d0bm00624f Xiang Ke 1 , Zhiyun Dong , Shuxian Tang , Wenlin Chu , Xiaoran Zheng , Li Zhen , Xingyu Chen , Chunmei Ding , Jun Luo , Jianshu Li
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-19 , DOI: 10.1039/d0bm00624f Xiang Ke 1 , Zhiyun Dong , Shuxian Tang , Wenlin Chu , Xiaoran Zheng , Li Zhen , Xingyu Chen , Chunmei Ding , Jun Luo , Jianshu Li
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Bioadhesives are of great interest for tissue/wound closure to reduce surgical time, minimize treatment invasiveness, and prevent body fluid leakage. However, bacterial infections remain a major concern during wound healing and tissue bonding. Hence, the development of bioadhesives with antibacterial properties is necessary. In this study, a hydrogel bioadhesive based on silk fibroin (SF) and tannic acid (TA) was combined with silver nanoparticles (AgNPs) generated in situ during hydrogel formation to improve its antibacterial abilities. In this system, TA can be regarded as a phenolic glue molecule to spontaneously co-assemble with SF to fabricate the adhesive matrix network and also as a reductant to induce silver nitrate to form AgNPs evenly within the adhesive network. Furthermore, the influence of the amount of silver nitrate was considered. The produced hybrid hydrogel bioadhesives with different amounts of AgNPs exhibited self-healing capabilities, considerable wet tissue adhesion strengths (14.32 ± 1.85 kPa–28.80 ± 2.29 kPa) and good cytocompatibility. When the initial concentration of silver nitrate was more than 0.05 wt%, the produced STA bioadhesive showed effective antibacterial properties in vitro. These results demonstrate that these STA bioadhesives have the potential to be used in tissue/wound closure, especially when bacterial infections are a main problem.
中文翻译：
天然聚合物基生物粘合剂，具有自愈性能和改善的抗菌性能。
生物粘合剂对于组织/伤口闭合以减少手术时间，最小化治疗侵入性并防止体液泄漏非常感兴趣。但是，细菌感染仍然是伤口愈合和组织粘合期间的主要问题。因此，需要开发具有抗菌特性的生物粘合剂。在这项研究中，将基于丝素蛋白（SF）和单宁酸（TA）的水凝胶生物粘合剂与原位生成的银纳米颗粒（AgNP）结合在一起在水凝胶形成过程中改善其抗菌能力。在该系统中，TA可被视为与SF自发共组装以形成胶粘剂基质网络的酚醛胶分子，也可被视为还原剂以诱导硝酸银在胶粘剂网络中均匀地形成AgNP。此外，考虑了硝酸银的量的影响。所生产的具有不同AgNP含量的杂化水凝胶生物胶粘剂具有自我修复能力，相当高的湿组织粘合强度（14.32±1.85 kPa–28.80±2.29 kPa）和良好的细胞相容性。当硝酸银的初始浓度大于0.05 wt％时，制得的STA生物胶粘剂在体外显示出有效的抗菌性能。这些结果表明，这些STA生物粘合剂具有用于组织/伤口闭合的潜力，尤其是当细菌感染是主要问题时。
更新日期：2020-07-28
中文翻译：
天然聚合物基生物粘合剂，具有自愈性能和改善的抗菌性能。
生物粘合剂对于组织/伤口闭合以减少手术时间，最小化治疗侵入性并防止体液泄漏非常感兴趣。但是，细菌感染仍然是伤口愈合和组织粘合期间的主要问题。因此，需要开发具有抗菌特性的生物粘合剂。在这项研究中，将基于丝素蛋白（SF）和单宁酸（TA）的水凝胶生物粘合剂与原位生成的银纳米颗粒（AgNP）结合在一起在水凝胶形成过程中改善其抗菌能力。在该系统中，TA可被视为与SF自发共组装以形成胶粘剂基质网络的酚醛胶分子，也可被视为还原剂以诱导硝酸银在胶粘剂网络中均匀地形成AgNP。此外，考虑了硝酸银的量的影响。所生产的具有不同AgNP含量的杂化水凝胶生物胶粘剂具有自我修复能力，相当高的湿组织粘合强度（14.32±1.85 kPa–28.80±2.29 kPa）和良好的细胞相容性。当硝酸银的初始浓度大于0.05 wt％时，制得的STA生物胶粘剂在体外显示出有效的抗菌性能。这些结果表明，这些STA生物粘合剂具有用于组织/伤口闭合的潜力，尤其是当细菌感染是主要问题时。
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