While radiopharmaceuticals incorporating rhenium-188 or rhenium-186 radioisotopes have been well documented in the literature, the labeling of rhenium complexes with alternative isotopes has received comparatively less attention. Such rhenium complexes have demonstrated significant utility in imaging melanoma tumors via complexation with α-melanocyte-stimulating hormone (α-MSH) analogues conjugated with radiometals and radiohalogens, improving fluorine-18 incorporation into ligands which were otherwise unable to be synthesized and elucidating improved understandings of rhenium mechanisms and coordination sites through deuterium incorporation. This review highlights each of these rhenium-labeling cases and discusses the benefits derived therein, thus providing a useful resource for researchers intending to label unique rhenium complexes.

中文翻译：

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标记的hen配合物：放射性氟化，α-MSH环化和氘取代

尽管在文献中已充分证明掺入188188或rh186放射性同位素的放射性药物，但是with配合物与其他同位素的标记受到的关注相对较少。此类rh配合物已通过与与放射性金属和放射性卤素缀合的α-黑素细胞刺激激素（α-MSH）类似物的络合，改善了氟18掺入否则无法合成的配体中并阐明了进一步的理解而在黑素瘤成像中显示出显着的实用性通过掺入rh的机制和协调位点 这篇综述重点介绍了这些these标记的情况，并讨论了其中的益处，从而为打算标记独特unique复合物的研究人员提供了有用的资源。