Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially in aged patients. Neuroinflammation has been closely associated with the development of POCD. While the contribution of pneumoperitoneum to the systemic inflammation has been well documented, the effect of pneumoperitoneal pressure on neuroinflammation and postoperative cognitive function remains unclear. In this study, we showed that high-pressure pneumoperitoneum promoted the postoperative neuroinflammation and microglial activation in the hippocampus and aggravated the postoperative cognitive impairment in aged mice. These results support the requirement to implement interventions with lower intra-abdominal pressure, which allows for adequate exposure of the operative field rather than a routine pressure.

中文翻译：

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高压气腹加重了手术诱导的老年小鼠神经炎症和认知功能障碍。

术后认知功能障碍（POCD）是手术后的常见并发症，尤其是在老年患者中。神经炎症与POCD的发展密切相关。虽然气腹对全身性炎症的贡献已得到充分证明，但气腹压力对神经炎症和术后认知功能的影响尚不清楚。在这项研究中，我们表明，高压气腹可以促进海马的术后神经炎症和小胶质细胞活化，并加重老年小鼠的术后认知障碍。这些结果支持以较低的腹腔内压力进行干预的要求，这允许充分暴露手术区域而不是常规压力。