Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD susceptibility. Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies. Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL-10 -1082A>G (rs1800896), -819T>C (rs1800871), and -592A>C (rs1800872) polymorphisms and BD susceptibility. Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings. Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included. Overall, significant associations between -819T>C polymorphisms and BD risk were observed in the total population (C vs. T: , , , ; TC vs. TT: , , , ; CC vs. TT: , , , ; TC+CC vs. TT: , , , ; and CC vs. TT+TC: , , , ). Moreover, the IL-10 -592 A>C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility. In summary, our meta-analysis suggested that IL-10 gene polymorphisms may play a salient role for BD development.

中文翻译：

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Interleukin-10 基因多态性与白塞氏病易感性之间的关联：来自荟萃分析的证据。


流行病学研究表明，白细胞介素-10 (IL-10) 多态性可能与白塞氏病 (BD) 的发生有关。然而，公布的结果并不一致。因此，进行这项荟萃分析是为了得出 IL-10 多态性与 BD 易感性之间更精确的关系。检索在线数据库（PubMed、Embase、科学引文索引 (SCI)、CNKI 和万方）以确定符合条件的研究。应用优势比 (OR) 和 95% 置信区间 (CI) 来评估 IL-10 -1082A>G (rs1800896)、-819T>C (rs1800871) 和 -592A>C (rs1800872) 多态性之间的关系强度和 BD 易感性。进行发表偏倚、敏感性和累积分析来衡量我们研究结果的稳健性。最后，纳入了 15 篇文章（36 项独立病例对照研究），涉及 5,971 名患者和 8,913 名对照者。总体而言，在总人群中观察到 -819T>C 多态性与 BD 风险之间存在显着相关性（C vs. 电话：, , , ; TC 对比 电报： , , , ; CC VS. 电报： , , , ; TC+CC 对比 电报： , , , ;和CC对比 TT+TC： , , , ）。此外，IL-10 -592 A>C 多态性和 ACC 单倍型对 BD 易感性表现出显着的保护作用。总之，我们的荟萃分析表明 IL-10 基因多态性可能在 BD 发展中发挥显着作用。