Backgrounds. Fatty acid synthase (FASN) has been regarded as a prognostic marker in prostate cancer (PCa). In this study, we evaluated FASN expression at both mRNA and protein levels and assessed the association between FASN expression and prognosis in male Han Chinese with PCa treated with radical prostatectomy (RP). Methods. Expression profile and prognostic value of FASN were analyzed in tissue microarray (TMA) and data retrieved from databases including TCGA public database, GEO database, and our sequencing data with whole clinicopathological characteristics. Results. FASN expression was associated with clinical parameters and biochemical recurrence of prostate cancer. The relative expression of FASN mRNA was higher in the tumor tissue in all public databases and our sequencing data (). A similar result was seen in tissue microarray (TMA) (). Analysis of our sequencing data indicated that FASN’s relative expression was associated with tumor stage (), and FASN expression was positively associated with the Gleason score () and seminal vesicle invasion () in TMA. We found that high FASN expression was an independent predictor of shorter BCR-free survival with univariate and multivariate survival analysis (), rendering FASN an optimal prognostic biomarker in male Han Chinese with prostate cancer. Conclusions. Our study demonstrated that FASN was overexpressed at mRNA and protein levels in PCa. We found that patients with high FASN expression had a shorter BCR-free survival, showing its value as a prognostic biomarker in male Han Chinese with PCa.

中文翻译：

---

FASN 蛋白过度表达表明前列腺癌的生化无复发生存率低。

背景。脂肪酸合酶 (FASN) 已被视为前列腺癌 (PCa) 的预后标志物。在这项研究中，我们评估了 FASN 在 mRNA 和蛋白质水平上的表达，并评估了 FASN 表达与接受根治性前列腺切除术 (RP) 治疗的 PCa 男性汉族患者预后之间的关联。方法。在组织微阵列 (TMA) 中分析了 FASN 的表达谱和预后价值，并从包括 TCGA 公共数据库、GEO 数据库在内的数据库中检索到的数据以及我们的具有完整临床病理学特征的测序数据。结果. FASN 表达与前列腺癌的临床参数和生化复发相关。在所有公共数据库和我们的测序数据中，FASN mRNA 在肿瘤组织中的相对表达量较高（）。在组织微阵列 (TMA) 中也看到了类似的结果（）。我们的测序数据分析表明，FASN 的相对表达与肿瘤分期相关（), FASN 表达与 Gleason 评分呈正相关 ()和精囊浸润 ()在 TMA 中。通过单变量和多变量生存分析，我们发现高 FASN 表达是较短的无 BCR 生存的独立预测因子。)，使 FASN 成为男性汉族前列腺癌患者的最佳预后生物标志物。结论。我们的研究表明，FASN 在 PCa 的 mRNA 和蛋白质水平上过表达。我们发现 FASN 高表达的患者无 BCR 生存期较短，显示其作为男性汉族 PCa 预后生物标志物的价值。