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The Role of the Microenvironment in Controlling the Fate of Bioprinted Stem Cells.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-06-19 , DOI: 10.1021/acs.chemrev.0c00126 Lauren N West-Livingston 1 , Jihoon Park 1 , Sang Jin Lee 1 , Anthony Atala 1 , James J Yoo 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-06-19 , DOI: 10.1021/acs.chemrev.0c00126 Lauren N West-Livingston 1 , Jihoon Park 1 , Sang Jin Lee 1 , Anthony Atala 1 , James J Yoo 1
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The field of tissue engineering and regenerative medicine has made numerous advances in recent years in the arena of fabricating multifunctional, three-dimensional (3D) tissue constructs. This can be attributed to novel approaches in the bioprinting of stem cells. There are expansive options in bioprinting technology that have become more refined and specialized over the years, and stem cells address many limitations in cell source, expansion, and development of bioengineered tissue constructs. While bioprinted stem cells present an opportunity to replicate physiological microenvironments with precision, the future of this practice relies heavily on the optimization of the cellular microenvironment. To fabricate tissue constructs that are useful in replicating physiological conditions in laboratory settings, or in preparation for transplantation to a living host, the microenvironment must mimic conditions that allow bioprinted stem cells to proliferate, differentiate, and migrate. The advances of bioprinting stem cells and directing cell fate have the potential to provide feasible and translatable approach to creating complex tissues and organs. This review will examine the methods through which bioprinted stem cells are differentiated into desired cell lineages through biochemical, biological, and biomechanical techniques.
中文翻译：
微环境在控制生物打印干细胞命运中的作用。
近年来，组织工程和再生医学领域在制造多功能、三维 (3D) 组织结构方面取得了许多进展。这可以归因于干细胞生物打印的新方法。生物打印技术有广泛的选择，多年来变得更加精细和专业，干细胞解决了生物工程组织结构的细胞来源、扩增和开发方面的许多限制。虽然生物打印干细胞提供了精确复制生理微环境的机会，但这种实践的未来在很大程度上依赖于细胞微环境的优化。为了制造可用于在实验室环境中复制生理条件或准备移植到活体宿主的组织构建体，微环境必须模拟允许生物打印干细胞增殖、分化和迁移的条件。生物打印干细胞和指导细胞命运的进步有可能为创建复杂的组织和器官提供可行且可转化的方法。本综述将研究生物打印干细胞通过生化、生物和生物力学技术分化成所需细胞谱系的方法。
更新日期：2020-06-19
中文翻译：
微环境在控制生物打印干细胞命运中的作用。
近年来，组织工程和再生医学领域在制造多功能、三维 (3D) 组织结构方面取得了许多进展。这可以归因于干细胞生物打印的新方法。生物打印技术有广泛的选择，多年来变得更加精细和专业，干细胞解决了生物工程组织结构的细胞来源、扩增和开发方面的许多限制。虽然生物打印干细胞提供了精确复制生理微环境的机会，但这种实践的未来在很大程度上依赖于细胞微环境的优化。为了制造可用于在实验室环境中复制生理条件或准备移植到活体宿主的组织构建体，微环境必须模拟允许生物打印干细胞增殖、分化和迁移的条件。生物打印干细胞和指导细胞命运的进步有可能为创建复杂的组织和器官提供可行且可转化的方法。本综述将研究生物打印干细胞通过生化、生物和生物力学技术分化成所需细胞谱系的方法。
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