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The effect of N-acetylcysteine in a combined antibiofilm treatment against antibiotic-resistant Staphylococcus aureus
Journal of Antimicrobial Chemotherapy ( IF 5.2 ) Pub Date : 2020-05-03 , DOI: 10.1093/jac/dkaa093
Arthika Manoharan 1 , Theerthankar Das 1 , Gregory S Whiteley 2 , Trevor Glasbey 2 , Frederik H Kriel 2 , Jim Manos 2
Affiliation  

The WHO declared Staphylococcus aureus as a ‘pathogen of high importance’ in 2017. One-fifth of all bloodstream-related infections in Australia and 12 000 cases of bacteraemia in the UK (2017–18) were caused by the MRSA variant. To address the need for novel therapies, we investigated several permutations of an innovative combination therapy containing N-acetylcysteine (NAC), an antibiotic and an enzyme of choice in eradicating MRSA and MSSA biofilms.

中文翻译:

的效果ñ乙酰半胱氨酸在对抗生素抗性的组合抗生物膜治疗金黄色葡萄球菌

世卫组织在2017年宣布金黄色葡萄球菌为“重要病原体”。澳大利亚所有与血液有关的感染的五分之一和英国(2017-18年)的12000例菌血症病例是由MRSA变异引起的。为了满足对新疗法的需求,我们研究了包含N-乙酰半胱氨酸(NAC),一种抗生素和一种选择的酶的创新性联合疗法在消除MRSA和MSSA生物膜方面的几种排列方式。
更新日期:2020-06-19
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