Bacterial population kinetics of strains harbouring drug resistance-conferring mutations within a patient often show cryptic resistance in clinical practice. We report a case that showed emergence and dominance of Mycobacterium tuberculosis with uncommon rpoB and gyrA mutations, followed by an rpoC compensatory mutation, during treatment.

中文翻译：

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在细菌群体动力学heteroresistant结核杆菌窝藏在罕见的抗性突变的gyrA和的rpoB意味着在预XDR-TB患者的突变的上位相互作用

在临床实践中，患者体内具有耐药性突变的菌株的细菌种群动力学常常显示出隐性耐药性。我们报告了一个案例，该案例显示在治疗过程中结核分枝杆菌的出现和优势与罕见的rpoB和gyrA突变，然后是rpoC代偿性突变。