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Inhaled tigecycline is effective against Mycobacterium abscessus in vitro and in vivo
Journal of Antimicrobial Chemotherapy ( IF 3.9 ) Pub Date : 2020-04-15 , DOI: 10.1093/jac/dkaa110
Camron Pearce 1 , Mike M Ruth 2 , Lian J Pennings 2 , Heiman F L Wertheim 2 , Amanda Walz 1 , Wouter Hoefsloot 3 , Carolien Ruesen 2 , Juan Muñoz Gutiérrez 1 , Mercedes Gonzalez-Juarrero 1 , Jakko van Ingen 2
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Mycobacterium abscessus causes chronic pulmonary infections. Owing to its resistance to most classes of antibiotics, treatment is complex and cure rates are only 45%. Tigecycline is active against M. abscessus, but severe toxicity and the need for IV administration limit its use.

中文翻译:

吸入替加环素在体外体内均可有效治疗脓肿分枝杆菌

脓肿分枝杆菌会引起慢性肺部感染。由于其对大多数抗生素的抗药性,因此治疗非常复杂,治愈率仅为45%。替加环素对脓肿支原体具有活性,但严重的毒性和静脉内给药的需求限制了其使用。
更新日期:2020-06-19
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