The present study examined the relationship between subthreshold depressive symptoms and gray matter volume in subregions of the posterior cerebellum. Structural magnetic resonance imaging data from 38 adults aged 51 to 80 years were analyzed along with participants’ responses to the Center for Epidemiologic Studies Depression Scale. Subscale scores for depressed mood, somatic symptoms, and lack of positive affect were calculated, and multiple regression analyses were used to examine the relationship between symptom dimensions and cerebellar volumes. Greater total depressive symptoms and greater somatic symptoms of depression were significantly related to larger volumes of vermis VI, a region within the salience network, which is altered in depression. Exploratory analyses revealed that higher scores on the lack of positive affect subscale were related to larger vermis VIII volumes. These results support that depressive symptom profiles have unique relationships within the cerebellum that may be important as the field move towards targeted treatment approaches for depression.

本研究检查了小脑后区域亚阈值抑郁症状与灰质体积之间的关系。分析了38位年龄在51至80岁的成年人的结构磁共振成像数据，以及参与者对流行病学研究中心抑郁量表的反应。计算情绪低落，躯体症状和缺乏积极影响的分量表分数，并使用多元回归分析检查症状尺寸与小脑体积之间的关系。抑郁症的总体总抑郁症状和躯体症状较大与显着网络中较大的of VI体积显着相关，VI在显着性网络中的区域在抑郁症中有所改变。探索性分析显示，缺少积极影响子量表的较高分数与较大的verVIII量有关。这些结果支持抑郁症状在小脑内具有独特的关系，这在该领域向抑郁症的靶向治疗方法发展中可能是重要的。