Bottom-Up Engineering of Responsive Hydrogel Materials for Molecular Detection and Biosensing,ACS Materials Letters

当前位置： X-MOL 学术 › ACS Mater. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bottom-Up Engineering of Responsive Hydrogel Materials for Molecular Detection and Biosensing
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-06-18 , DOI: 10.1021/acsmaterialslett.0c00204
Jason Y. C. Lim ₁ , Shermin S. Goh ₁ , Xian Jun Loh ₁

Affiliation

Molecular sensors respond to target molecules in their surroundings to detect and sometimes even quantify their concentrations. Traditionally comprised of small organic molecules or metal complexes, these technologies have been essential to biomedical and environmental monitoring, ensuring human health, safety, and general well-being. In the past two decades, analyte-responsive hydrogels have been an emerging technology receiving vast research attention worldwide. Hydrogels capable of detecting a vast array of analytes, including inorganic ions, carbohydrates, thiols, gases, biomolecules (nucleic acids and proteins), and even microorganisms such as bacteria and viruses, have been developed. With the added advantages of bottom-up design at the molecular level and biocompatibility, molecular detection using hydrogel sensors is typically simple to perform, and hydrogels can be integrated with electronic devices to enhance detection sensitivity, or with biomedical devices for in vitro and in vivo studies. Herein, we discuss a range of innovative strategies that have been developed for engineering hydrogel molecular sensors, with emphasis on “bottom-up” molecular engineering to achieve analyte selectivity and sensitivity.

中文翻译：

用于分子检测和生物传感的响应水凝胶材料的自下而上工程

分子传感器对周围环境中的目标分子作出反应，以检测甚至量化其浓度。传统上，这些技术由小的有机分子或金属配合物组成，对于生物医学和环境监测，确保人类健康，安全和整体健康至关重要。在过去的二十年中，分析物响应型水凝胶已成为一项新兴技术，在世界范围内受到了广泛的研究关注。已经开发出了能够检测多种分析物的水凝胶，包括无机离子，碳水化合物，硫醇，气体，生物分子（核酸和蛋白质），甚至是微生物，例如细菌和病毒。自下而上的设计在分子水平和生物相容性方面具有更多优势，体外和体内研究。本文中，我们讨论了为工程水凝胶分子传感器开发的一系列创新策略，重点是“自下而上”的分子工程以实现分析物的选择性和灵敏度。

更新日期：2020-08-03

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11