Background

Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS). However, the application of amantadine in UWS after cerebral hemorrhage has only been rarely reported. This allows for a further exploration of the role of amantadine in the treatment of UWS resulting from a severe cerebral hemorrhage.

Methods

We observed the changes of seven patients with UWS of intracerebral hemorrhage after taking amantadine. We also carried out a detailed neurological examination of the patient with disorders of consciousness to include or exclude subjects for the study. CRS-R score was used to evaluate the neurological recovery.

Results

An improvement in consciousness was observed within 3–6 days after the start of amantadine administration in all seven cases (n = 7/7; 100%). Five patients recovered conscious and left aphasia, hemiplegia and other sequelae, and two patients recovered from UWS to minimally conscious state (MCS).

Conclusions

In this study, amantadine administration showed substantial positive effects on recovery following severe cerebral hemorrhage. We recommend further randomized controlled studies to determine the efficacy of amantadine.

中文翻译：

---

金刚烷胺在严重脑出血后无反应的清醒综合征患者中的使用。

背景

金刚烷胺目前被推荐用于无反应性清醒综合征（UWS）的颅脑外伤患者。但是，金刚烷胺在脑出血后在UWS中的应用很少报道。这可以进一步探讨金刚烷胺在严重脑出血引起的UWS治疗中的作用。

方法

我们观察了7名服用金刚烷胺的UWS脑出血患者的变化。我们还对意识障碍患者进行了详细的神经系统检查，以纳入或排除研究对象。CRS-R评分用于评估神经功能恢复。

结果

在所有金刚烷胺治疗开始后的3到6天内，意识得到了改善（n = 7/7； 100％）。5例患者恢复了自觉性和左眼失语，偏瘫和其他后遗症，2例患者从UWS恢复到了最低意识状态（MCS）。

结论

在这项研究中，金刚烷胺给药对严重脑出血后的恢复显示出显着的积极作用。我们建议进行进一步的随机对照研究以确定金刚烷胺的疗效。