Abstract

Food protein-derived bioactive peptides, particularly antihypertensive peptides, are important constituents of functional foods or nutraceuticals. Most antihypertensive are identified as the inhibitors of angiotensin converting enzyme (ACE), a key enzyme responsible for the generation of angiotensin II (Ang II), which is a vasoconstricting peptide. Hence, ACE has long been used as a universal target to identify antihypertensive peptides. Angiotensin converting enzyme 2 (ACE2), is a homolog of ACE but uses Ang II as its key substrate to produce angiotensin (1–7), exerting vasodilatory activity via the mas receptor (MasR). Therefore, ACE2 functions in the opposite way as ACE and is an emerging novel target for cardiovascular therapy. The potential of food protein-derived bioactive peptides in targeting ACE2 has been rarely explored. While, recently we found that IRW, an egg white ovotransferrin-derived antihypertensive peptide, reduced blood pressure in spontaneously hypertensive rats via the ACE2/Ang (1–7)/MasR axis, indicating a new mechanism of food protein-derived bioactive peptides in reducing blood pressure. The objectives of this review are to summarize the functions of the ACE2/Ang (1–7)/MasR axis and to examine its potential roles in the actions of food protein-derived antihypertensive peptides. The interaction between antihypertensive peptides and the ACE2/Ang (1–7)/MasR axis will also be discussed.

摘要

食物蛋白衍生的生物活性肽，特别是抗高血压肽，是功能性食品或保健品的重要成分。大多数抗高血压药被确定为血管紧张素转换酶 (ACE) 的抑制剂，这是一种负责生成血管紧张素 II (Ang II) 的关键酶，血管紧张素 II (Ang II) 是一种血管收缩肽。因此，ACE 长期以来一直被用作鉴定抗高血压肽的通用靶标。血管紧张素转换酶 2 (ACE2) 是 ACE 的同源物，但使用 Ang II 作为其关键底物来产生血管紧张素 (1-7)，通过 mas 受体 (MasR) 发挥血管舒张活性。因此，ACE2的作用与ACE相反，是心血管治疗的新兴新靶点。很少探索食物蛋白衍生的生物活性肽在靶向 ACE2 方面的潜力。尽管，最近我们发现蛋清卵转铁蛋白衍生的降压肽IRW通过ACE2/Ang（1-7）/MasR轴降低自发性高血压大鼠的血压，表明食物蛋白衍生的生物活性肽在降血脂方面的新机制压力。本综述的目的是总结 ACE2/Ang (1-7)/MasR 轴的功能，并检查其在食物蛋白衍生的抗高血压肽作用中的潜在作用。还将讨论抗高血压肽与 ACE2/Ang (1-7)/MasR 轴之间的相互作用。本综述的目的是总结 ACE2/Ang (1-7)/MasR 轴的功能，并检查其在食物蛋白衍生的抗高血压肽作用中的潜在作用。还将讨论抗高血压肽与 ACE2/Ang (1-7)/MasR 轴之间的相互作用。本综述的目的是总结 ACE2/Ang (1-7)/MasR 轴的功能，并检查其在食物蛋白衍生的抗高血压肽作用中的潜在作用。还将讨论抗高血压肽与 ACE2/Ang (1-7)/MasR 轴之间的相互作用。