Abstract

Nucleophilic substitution of hydrogen in nitroarenes has become a powerful synthetic tool for functionalization of these important organic substrates, complementary to other modern methods. In this review we present new developments in the area of introduction of alkyl and functionalized alkyl substituents into nitroarene rings via nucleo­philic substitution of hydrogen, followed by application of these processes in the construction of carbo- and heterocyclic rings. Finally, new developments in the investigation of the mechanism of S_NArH are summarized.

1 Introduction

2 Alkylation and Haloalkylation

3 Functionalized Carbon Substituents

4 Formation of Carbo- and Heterocyclic Rings

5 Mechanistic Aspects of S_NArH

6 Conclusion

中文翻译：

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通过亲核性氢取代将碳取代基引入硝基芳烃：新进展

摘要

硝基芳烃中氢的亲核取代已成为这些重要有机底物功能化的强大合成工具，是对其他现代方法的补充。在这篇综述中，我们介绍了通过氢的亲核取代将烷基和官能化烷基取代基引入硝基芳烃环的新进展，然后将这些方法应用于碳环和杂环的构建。最后，总结了S _N ArH机理研究的新进展。

1引言

2烷基化和卤代烷基化

3功能化碳取代基

4碳环和杂环的形成

S _N ArH的5个机械方面

六，结论