Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments. 1 Introduction 2 Strategy 1: Ambiphilic Fluorine Sources 3 Strategy 2: Oxidant and Fluoride 4 Conclusions and Outlook

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烯烃邻位二氟化：从氟气到更有利的条件

邻位二氟化烷烃是与药物化学相关的实体，可通过烯烃的二氟化获得。该反应已经从使用高反应性和不安全的试剂（其提供较差的官能团耐受性和选择性）发展到使用更安全和更具选择性的试剂，从而有助于获得更广泛的底物。在这篇评论文章中，我们描述了这些发展的细节。1 引言 2 策略 1：双亲氟源 3 策略 2：氧化剂和氟化物 4 结论和展望