Amorphous pharmaceuticals often suffer from poor physical stability, which can negate their high solubility, fast dissolution rate, and better oral bioavailability vs. crystalline forms. This represents a major hurdle to processing, storage, and delivery of amorphous pharmaceuticals. Several approaches to addressing these problems have been pursued, but there is still a need for a general method for stabilizing the amorphous form. We describe a novel approach using a water-unstable metal-organic framework as a drug delivery vehicle that demonstrates improved amorphous form stability accompanied by remarkably enhanced solubility and a fast dissolution rate. This research project spanned eleven years from conception to realization and dissemination. With origins in understanding the stability or porous solids for energy storage materials, the work also highlights potential of basic science understanding to illuminate new areas of application.

中文翻译：

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利用框架不稳定性：从储能到药物输送的旅程

无定形药物通常具有较差的物理稳定性，这可能会抵消它们的高溶解度、快速溶出度和与结晶形式相比更好的口服生物利用度。这代表了无定形药物的加工、储存和交付的主要障碍。已经探索了几种解决这些问题的方法，但仍然需要一种稳定无定形形式的通用方法。我们描述了一种使用对水不稳定的金属有机骨架作为药物递送载体的新方法，该方法表现出改善的无定形形式稳定性，伴随着显着增强的溶解度和快速溶解速率。这个研究项目从构思到实现和传播跨越了十一年。源于对储能材料稳定性或多孔固体的理解，