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Asymmetric Alkynylation of Cyclic N‐Sulfonyl Imines using Synergistic Chiral Phosphoric Acid/Copper Catalysis
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-06-18 , DOI: 10.1002/adsc.202000504 Ya‐Ling Li 1 , Jin‐Xin Liu 1 , Xiao‐Pan Chen 1 , Yuan Zhou 1 , You‐Cai Xiao 1 , Fen‐Er Chen 1, 2, 3
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-06-18 , DOI: 10.1002/adsc.202000504 Ya‐Ling Li 1 , Jin‐Xin Liu 1 , Xiao‐Pan Chen 1 , Yuan Zhou 1 , You‐Cai Xiao 1 , Fen‐Er Chen 1, 2, 3
Affiliation
The catalytic enantioselective alkynylation of six‐membered cyclic N‐sulfonyl imines was achieved using a cooperative chiral phosphoric acid and Cu(I) catalyst. This alkynylation reaction displays a broad substrate scope for both terminal alkynes and benzoxathiazine 2,2‐dioxides and provides a highly efficient method for the synthesis of chiral propargylic sulfamidates in up to 95% yield and 99% enantiomeric excess.
中文翻译:
协同手性磷酸/铜催化不对称环N-磺酰基亚胺烷基化
六元环状N-磺酰基亚胺的催化对映选择性炔基化反应是通过协同手性磷酸和Cu(I)催化剂实现的。该炔基化反应显示了末端炔烃和苯并恶嗪2,2-二氧化物的广泛底物范围,并提供了一种高效合成手性炔丙基磺酰胺酸酯的高效方法,产率高达95%,对映体过量99%。
更新日期:2020-08-04
中文翻译:
协同手性磷酸/铜催化不对称环N-磺酰基亚胺烷基化
六元环状N-磺酰基亚胺的催化对映选择性炔基化反应是通过协同手性磷酸和Cu(I)催化剂实现的。该炔基化反应显示了末端炔烃和苯并恶嗪2,2-二氧化物的广泛底物范围,并提供了一种高效合成手性炔丙基磺酰胺酸酯的高效方法,产率高达95%,对映体过量99%。