Asymmetric Alkynylation of Cyclic N‐Sulfonyl Imines using Synergistic Chiral Phosphoric Acid/Copper Catalysis,Advanced Synthesis & Catalysis

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Asymmetric Alkynylation of Cyclic N‐Sulfonyl Imines using Synergistic Chiral Phosphoric Acid/Copper Catalysis
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-06-18 , DOI: 10.1002/adsc.202000504
Ya‐Ling Li ₁ , Jin‐Xin Liu ₁ , Xiao‐Pan Chen ₁ , Yuan Zhou ₁ , You‐Cai Xiao ₁ , Fen‐Er Chen _{1,

2,

3}

Affiliation

The catalytic enantioselective alkynylation of six‐membered cyclic N‐sulfonyl imines was achieved using a cooperative chiral phosphoric acid and Cu(I) catalyst. This alkynylation reaction displays a broad substrate scope for both terminal alkynes and benzoxathiazine 2,2‐dioxides and provides a highly efficient method for the synthesis of chiral propargylic sulfamidates in up to 95% yield and 99% enantiomeric excess.

中文翻译：

协同手性磷酸/铜催化不对称环N-磺酰基亚胺烷基化

六元环状N-磺酰基亚胺的催化对映选择性炔基化反应是通过协同手性磷酸和Cu（I）催化剂实现的。该炔基化反应显示了末端炔烃和苯并恶嗪2,2-二氧化物的广泛底物范围，并提供了一种高效合成手性炔丙基磺酰胺酸酯的高效方法，产率高达95％，对映体过量99％。

更新日期：2020-08-04

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