Calcium (Ca) and silica (Si) ions have attracted intense interest in biomedical applications. The two ions are directly involved in many biological processes; for instance, Ca plays a key role in regulating cellular responses to bioceramics, promoting cell growth, and differentiation into osteoblasts. Si plays a significant role in bone calcification and is helpful for bone density improvement and inhibiting osteoporosis. Calcium silicate ceramics including a large group of trace metal containing calcium silicate‐based compounds are involved in biomedical applications such as repairing hard tissue texture, bone scaffolds, bone cements, or implant coatings. The aim of the study is to provide a comprehensive overview of developments in research on calcium silicate‐based ceramics, such as wollastonite (CaSiO₃), diopside (CaMgSi₂O₆), akermanite (Ca₂MgSi₂O₇), bredigite (Ca₇Mg(SiO₄)₄), merwinite (Ca₃MgSi₂O₈), monticellite (CaMgSiO₄), hardystonite (Ca₂Zn(Si₂O₇), and baghdadite (Ca₃ZrSi₂O₉), including degradation, apatite mineralization, and mechanical properties. Finally, the biological in vitro and in vivo presentation for bone tissue repair are summarized, which show promise with regard to application of calcium silicate‐based ceramics as bone repair and replacement materials.

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骨组织工程中基于硅酸钙的生物陶瓷的评论

钙（Ca）和二氧化硅（Si）离子在生物医学应用中引起了浓厚的兴趣。这两个离子直接参与许多生物过程。例如，钙在调节细胞对生物陶瓷的反应，促进细胞生长以及分化为成骨细胞中起着关键作用。Si在骨钙化中起重要作用，并有助于改善骨密度和抑制骨质疏松。包括大量含痕量金属的硅酸钙基化合物的硅酸钙陶瓷涉及生物医学应用，例如修复硬组织质地，骨支架，骨水泥或植入物涂层。本研究的目的是对硅酸钙基陶瓷（例如硅灰石（CaSiO ₃），透辉石（CaMgSi ₂ O ₆），钙钛矿（Ca ₂ MgSi ₂ O ₇），石（Ca ₇ Mg（SiO ₄）₄），皂石（Ca ₃ MgSi ₂ O ₈），蒙脱石（CaMgSiO ₄），硬钙石（Ca Ca ₂ Zn（Si ₂ O ₇）和巴格达特（Ca ₃ ZrSi ₂ O ₉），包括降解，磷灰石矿化和机械性能。最后，总结了用于骨骼组织修复的生物学上和体外的表现，这在将硅酸钙基陶瓷用作骨骼修复和替代材料方面显示出了希望。