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2‐Deoxyglucose terminates pilocarpine‐induced status epilepticus in neonatal rats
Epilepsia ( IF 6.6 ) Pub Date : 2020-06-19 , DOI: 10.1111/epi.16583
Remi Janicot 1 , Carl E Stafstrom 1 , Li-Rong Shao 1
Affiliation  

Neonatal status epilepticus (SE) is a life‐threatening medical emergency. Unfortunately, up to 50% of neonates with SE are resistant to current antiseizure drugs, highlighting the need for better treatments. This study aims to explore a novel metabolic approach as a potential alternative treatment to control neonatal SE, using the glycolytic inhibitor 2‐deoxyglucose (2‐DG).

中文翻译:

2-脱氧葡萄糖终止毛果芸香碱诱导的新生大鼠癫痫持续状态

新生儿癫痫持续状态 (SE) 是一种危及生命的医疗急症。不幸的是,多达 50% 的 SE 新生儿对当前的抗癫痫药有抗药性,这凸显了对更好治疗的需求。本研究旨在探索一种新的代谢方法,作为控制新生儿 SE 的潜在替代疗法,使用糖酵解抑制剂 2-脱氧葡萄糖 (2-DG)。
更新日期:2020-06-19
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