Extracts and steroids from the edible mushroom Hypholoma lateritium exhibit anti‐inflammatory properties by inhibition of COX‐2 and activation of Nrf2,Chemistry & Biodiversity

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Extracts and steroids from the edible mushroom Hypholoma lateritium exhibit anti‐inflammatory properties by inhibition of COX‐2 and activation of Nrf2
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-08-03 , DOI: 10.1002/cbdv.202000391
Attila Ványolós _{1,

2} , Bożena Muszyńska ₃ , Bayar Chuluunbaatar ₁ , Joanna Gdula-Argasińska ₄ , Katarzyna Kała ₃ , Judit Hohmann _{1,

5}

Affiliation

Hypholoma lateritium is an edible macrofungus with a common distribution in Europe, North America, and the Far East. The aim of this study was to investigate the potential anti‐inflammatory effects of H. lateritium extracts and its isolated steroids: fasciculic acid B, fasciculol E, fasciculol C, lanosta‐7,9(11)‐diene‐12β,21α‐epoxy‐2α,3β,24β,25‐tetraol, fasciculol F, and demethylincisterol A2. Organic (hexane, chloroform and 50 % methanol) and water extracts of H. lateritium were subjected to in vitro assays to determine pro‐inflammatory protein levels, such as cyclooxygenase‐2 (COX‐2), cytosolic prostaglandin E2 synthase (cPGES), and antioxidant nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2). Fungal extracts demonstrated significant activities on pro‐inflammatory protein levels with minor differences among the activities of the fractions of different polarities. All the compounds proved to exert notable inhibitory properties on COX‐2 and were capable to stimulate the Nrf2 pathway. Fungal extracts and the compounds exerted no cytotoxic activities on RAW 264.7 cells.

中文翻译：

食用菌Hypholoma lateritium的提取物和类固醇通过抑制COX-2和激活Nrf2表现出抗炎特性

Hypholoma lateritium 是一种可食用的大型真菌，常见于欧洲、北美和远东地区。本研究的目的是研究红土提取物及其分离的类固醇的潜在抗炎作用： fasciculic acid B、fasciculol E、fasciculol C、lanosta-7,9(11)-diene-12β,21α-epoxy ‐2α,3β,24β,25-四醇、fasciculol F 和 demethylincisterol A2。对红土的有机提取物（己烷、氯仿和 50% 甲醇）和水提取物进行体外测定，以确定促炎蛋白水平，如环氧合酶-2 (COX-2)、细胞溶质前列腺素 E2 合酶 (cPGES)、和抗氧化核因子（红细胞衍生的 2）样 2（Nrf2）。真菌提取物对促炎蛋白水平具有显着活性，不同极性组分的活性差异很小。所有化合物都被证明对 COX-2 具有显着的抑制作用，并且能够刺激 Nrf2 通路。真菌提取物和化合物对 RAW 264.7 细胞没有细胞毒性活性。

更新日期：2020-08-03

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