Subjective memory complaints (SMCs) may be an important early indicator of cognitive aging and preclinical Alzheimer's disease risk. This study investigated whether age-related differences in right or left hippocampal volume underlie SMCs, if these relationships differ by hypertension status, and how they are related to objective memory performance in a group of 190 healthy older adults, 50-89 years of age. Analyses revealed a significant mediation of the relationship between age and mild SMCs by right hippocampal volume that was moderated by hypertension status. This moderated mediation effect was not observed with left hippocampal volume. Additionally, a moderated serial mediation model showed that age predicted right hippocampal volume, which predicted SMCs, and in turn predicted objective memory performance on several measures of verbal selective reminding in individuals with hypertension, but not in non-hypertensives. Together, these findings suggest that even mild SMCs, in the context of hypertension, provide an early indicator of cognitive aging, reflecting a potential link among vascular risk, SMCs, and the preclinical risk for Alzheimer's disease.

中文翻译：

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右侧海马体积对主观记忆抱怨的调节因健康老龄化高血压状态而异

主观记忆投诉 (SMC) 可能是认知老化和临床前阿尔茨海默病风险的重要早期指标。本研究调查了与年龄相关的左右海马体积差异是否是 SMC 的基础，这些关系是否因高血压状态而异，以及它们如何与 190 名 50-89 岁的健康老年人的客观记忆表现相关。分析显示，右侧海马体积对年龄和轻度 SMC 之间的关系有显着的中介作用，而高血压状态可调节这种关系。左海马体积没有观察到这种适度的中介效应。此外，一个缓和的串行中介模型显示，年龄预测右海马体积，预测 SMC，反过来，在高血压患者中预测了几种口头选择性提醒的客观记忆表现，但在非高血压患者中则不然。总之，这些研究结果表明，即使是轻度的 SMC，在高血压的背景下，也可以提供认知老化的早期指标，反映血管风险、SMC 和阿尔茨海默病的临床前风险之间的潜在联系。