Journal of Proteomics ( IF 2.8 ) Pub Date : 2020-06-19 , DOI: 10.1016/j.jprot.2020.103881 Hossein Aghamollaei 1 , Shahram Parvin 1 , Alireza Shahriary 1
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Visual impairment and blindness is a major health burden worldwide, and major ocular diseases causing visual impairment pertain to the anterior segment of the eye. Anterior segment ocular diseases are common, yet complex entities. Although many treatment options and surgical techniques are available for these ailments, the underlying cause and pathogenesis is still unclear. Finding ways to fundamentally treat these patients and rectify the underlying dysregulations leading to the disease may help cure patients completely without major complications. Proteomics approaches are a novel way to distinguish dysregulated proteins in a variety of biological tissues in a hypothesis-free manner, thus helping to find the responsible pathways leading to a certain disease. The aim of the current study is to review the available knowledge in scientific literature regarding the proteomics studies done on anterior segment eye diseases and suggest potential clinical implications to exploit the results of these studies.
Significance
Anterior segment ocular diseases are responsible for a major proportion of visual impairment and blindness worldwide. Although ophthalmologists have several treatment options that can alleviate or control the progression of these diseases, no definite cure is available for most of them. Moreover, because these diseases are progressive, prompt diagnosis is of utmost important. Proteomics studies enable us to identify and quantify the dysregulated proteins in a biological specimen in a hypothesis-free manner. Understanding the dysregulated protein pathways shines a light on the pathogenesis of the disease. Moreover, these dysregulated proteins may act as biomarkers to help in diagnosis and treatment follow-up. Hence, in this article we sought out to review the available scientific literature regarding the proteomics studies of anterior segment ocular diseases and to identify potential applications of proteomic studies in clinic.
中文翻译：
蛋白质组学方法对影响前节的眼部疾病的评价。
视力障碍和失明是世界范围内的主要健康负担，导致视力障碍的主要眼部疾病属于眼前段。前段眼病是常见的但复杂的实体。尽管有许多治疗方法和手术技术可用于这些疾病，但其根本原因和发病机制仍不清楚。寻找从根本上治疗这些患者并纠正导致该疾病的潜在失调的方法可能有助于完全治愈患者而无重大并发症。蛋白质组学方法是一种以无假设的方式区分各种生物组织中失调的蛋白质的新颖方法，从而有助于找到导致某种疾病的负责任途径。
意义
前段眼部疾病是导致全世界视力障碍和失明的主要原因。尽管眼科医生有几种可以减轻或控制这些疾病进展的治疗选择，但对于大多数疾病而言，尚无明确的治疗方法。此外，由于这些疾病是进行性疾病，因此迅速诊断至关重要。蛋白质组学研究使我们能够以无假设的方式鉴定和定量生物标本中失调的蛋白质。了解失调的蛋白质途径为该疾病的发病机理提供了启示。此外，这些失调的蛋白质可能充当生物标志物，以帮助诊断和治疗随访。因此，
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