Journal of Proteomics ( IF 2.8 ) Pub Date : 2020-06-19 , DOI: 10.1016/j.jprot.2020.103880 Elisabetta Chiaradia 1 , Ingrid Miller 2
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Equine medicine represents a relevant field of veterinary science and the horse industry generates a significant economic impact. Horses can be involved in different sport disciplines, meat production, work and recreational purposes. Horses are also important for human health as they can be used as animal models for studying human diseases and in equine-assisted therapy. This review summarizes the data related to body fluids such as plasma/serum, urine, cerebrospinal fluid, synovial fluid, saliva, bronchoalveolar lavage fluid and peritoneal fluid obtained using proteomic analysis. Horse body fluid proteome analysis under various physiological and pathological conditions is a useful method for identifying new biomarkers for horse diseases which are still difficult to diagnose, but with serious consequences on equine health and welfare. The findings reported here reveal that further proteomic studies on equine body fluids collected from diseased animals are required.
Significance
Body fluids are sources of potential protein biomarkers for diagnosis and therapeutic target identification. Indeed, they contain proteins that play a crucial role in cell functions and whose presence or relative abundance are indicative of the health status of tissues/organs. The review reports the data on the equine body fluids obtained using proteomic analysis, including those which are commonly used to obtain a correct diagnosis and prognosis of horse diseases which still pose a significant challenge. For equine medicine, new biomarkers are needed to formulate early diagnosis and to distinguish among diseases with similar clinical signs.
中文翻译：
以缓慢的速度向马体液中的蛋白质组迁移。
马医学代表了兽医学的一个相关领域，马业产生了重大的经济影响。马可能参与不同的运动学科，肉类生产，工作和娱乐目的。马对于人类健康也很重要，因为它们可以用作研究人类疾病和马辅助疗法的动物模型。这篇综述总结了与体液有关的数据，如血浆/血清，尿液，脑脊液，滑膜液，唾液，支气管肺泡灌洗液和通过蛋白质组学分析获得的腹膜液。在各种生理和病理条件下进行的马体液蛋白质组分析是一种有用的方法，可用于识别仍难以诊断但对马的健康和福祉造成严重后果的马疾病的新生物标志物。
意义
体液是用于诊断和治疗目标识别的潜在蛋白质生物标志物的来源。实际上，它们包含在细胞功能中起关键作用的蛋白质，其存在或相对丰度指示组织/器官的健康状况。该评价报告了使用蛋白质组学分析获得的马体液的数据，包括通常用于正确诊断和预后马病的马水，这些疾病仍然构成重大挑战。对于马医学，需要新的生物标志物来制定早期诊断并区分具有相似临床症状的疾病。
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