Human Immunology ( IF 2.7 ) Pub Date : 2020-06-19 , DOI: 10.1016/j.humimm.2020.06.003 Emilio Q. Villanueva , Chi-Cheng Li , Py-Yu Lin , Kuo-Liang Yang
In this report, HLA polymorphisms (A, B, and DRB1 loci) were determined in 51 unrelated Filipinos. Molecular genotyping was carried out by sequence-based typing (Sanger sequencing). Data were analyzed by HLA-net GENE[RATE] tools. HLA-A, -B and -DRB1 genotype frequencies were at Hardy-Weinberg equilibrium. A*11, B*15, and DRB1*15 were the most frequent allele groups, while A*11-B*15-DRB1*15 was the most frequent HLA-A-B-DRB1 haplotype. HLA data are available in the Allele Frequencies Net Database (AFND: 3690) under the population name “Philippines National Capital Region”.
中文翻译:
居住在菲律宾国家首都地区的菲律宾人中HLA-A,-B和-DRB1的基因型和单倍型频率。
在此报告中,在51个不相关的菲律宾人中确定了HLA多态性(A,B和DRB1基因座)。分子基因分型是通过基于序列的打字(Sanger测序)进行的。数据通过HLA-net GENE [RATE]工具进行分析。HLA-A,-B和-DRB1基因型频率处于Hardy-Weinberg平衡状态。A * 11,B * 15和DRB1 * 15是最常见的等位基因组,而A * 11-B * 15-DRB1 * 15是最常见的HLA-AB-DRB1单倍型。HLA数据可从等位基因频率数据库(AFND:3690)中以“菲律宾国家首都地区”的人口名称获得。