Raspberry ketone (RK; [4-(4-hydroxyphenyl)-2-butanone]) is used by the food and cosmetic industry as a flavoring agent. RK is also marketed as a dietary supplement for weight maintenance and appetite control. The purpose of the study was to characterize the acute feeding suppression with RK (64–640 mg/kg) by oral gavage in male and female C57BL/6J mice. Cumulative 24 h food intake was reduced at 200 mg/kg (24% feeding suppression) in males and reliably reduced at 640 mg/kg (49–77% feeding suppression). Feeding suppression was not associated with pica behavior over the range of doses or conditioned taste aversion. In a separate experiment, a single oral gavage of RK (640 mg/kg) resulted in approximate 43% mortality rate (6 out 14 male mice) within 2 days. Atrophy of white adipose tissue, splenic abnormalities, and thymus involution were noted after 2–4 days after oral gavage RK. Total white blood cell count, lymphocytes, monocytes, eosinophils were significantly lower, while mean red blood cells, hemoglobin, and hematocrit were significantly higher with RK treatment. Our findings indicated a dose-dependent feeding suppression with acute RK, but doses that reliable suppress food intake are associated with pathological changes.

覆盆子酮（RK；[4-(4-羟基苯基)-2-丁酮]）在食品和化妆品工业中用作调味剂。RK 还作为用于维持体重和控制食欲的膳食补充剂进行销售。本研究的目的是表征雄性和雌性 C57BL/6J 小鼠经口强饲 RK (64–640 mg/kg) 的急性摄食抑制作用。雄性的累积 24 小时食物摄入量在 200 mg/kg（24% 摄食抑制）时减少，在 640 mg/kg（49-77% 摄食抑制）时可靠地减少。进食抑制与剂量范围内的异食癖行为或条件性味觉厌恶无关。在一项单独的实验中，单次口服 RK（640 毫克/千克）导致 2 天内死亡率约为 43%（14 只雄性小鼠中有 6 只）。口服 RK 后 2-4 天，观察到白色脂肪组织萎缩、脾脏异常和胸腺退化。RK 治疗后，白细胞总数、淋巴细胞、单核细胞、嗜酸性粒细胞显着降低，而平均红细胞、血红蛋白和血细胞比容显着升高。我们的研究结果表明，急性 RK 存在剂量依赖性摄食抑制，但可靠抑制食物摄入的剂量与病理变化相关。