Abstract Despite their great potential in biomedical applications, the use of hydrogels has been severely limited by their swelling property and weak strength under physiological conditions. Herein, we developed nonswelling and high-strength hydrogels by a facile one-step thiol-acrylate photopolymerization of methacrylated poly (vinyl alcohol) and thiol-terminated poly (vinyl alcohol) for the first time. The hydrogels can gel rapidly within 7 s in this approach. By controlling crosslinking density and hydrophilic/hydrophobic balance of cross-linking hydrogel networks, the properties of hydrogels can be tunable and can even exhibit an excellent nonswelling behaviour under physiological conditions. Notably, the outstanding mechanical property with a compressive strength of 7.0 MPa at ~95% strain as well as no damage through compressive stress–strain tests in the allowable scope of tensile tester can also be achieved. Moreover, the hydrogel is non-toxic to L929 cells, which is favorable for promising biomedical applications as implants and tissue engineering scaffolds.

中文翻译：

---

具有高强度的快速凝胶和非溶胀光聚合聚（乙烯醇）水凝胶

摘要 尽管水凝胶在生物医学应用中具有巨大潜力，但由于其在生理条件下的溶胀性和弱强度，其使用受到严重限制。在此，我们首次通过甲基丙烯酸化聚（乙烯醇）和硫醇封端的聚（乙烯醇）的简单一步硫醇-丙烯酸酯光聚合开发了不溶胀和高强度水凝胶。在这种方法中，水凝胶可以在 7 秒内快速凝胶化。通过控制交联水凝胶网络的交联密度和亲水/疏水平衡，水凝胶的性质可以调节，甚至可以在生理条件下表现出优异的非膨胀行为。值得注意的是，出色的机械性能，抗压强度为 7。还可以在拉伸试验机的允许范围内通过压缩应力 - 应变测试在 ~95% 应变下达到 0 MPa 以及无损坏。此外，该水凝胶对 L929 细胞无毒，有利于作为植入物和组织工程支架的有前途的生物医学应用。